tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596587, compound

HRID 612859Notes

Reaction equation

HRID 612859 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10](NO)[CH:9]=2)=[CH:4][CH:3]=1.[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][OH:25])=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][O:25][C:10]1[CH:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[O:12][N:11]=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 19596548HCID 19596548, compound

Product 1

HCID 19596587HCID 19596587, compoundYield 74%

Procedure

5-(4-Chlorophenyl)-3-hydroxyaminoisoxazole (0.58 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.48 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 1(a) to obtain the title compound (0.69 g, 68%) as colorless crystals.

Sources & evidence

ORD record
ord-e89b9070bee842dd88765e1b71f75e95
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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