tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596585, compound

HRID 612860Notes

Reaction equation

HRID 612860 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([C:7]2[S:8][CH:9]=[CH:10][CH:11]=2)[O:4][N:3]=1.[C:12]([O:16][C:17]([NH:19][CH2:20][CH2:21]O)=[O:18])([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][C:17]([NH:19][CH2:20][CH2:21][O:1][C:2]1[CH:6]=[C:5]([C:7]2[S:8][CH:9]=[CH:10][CH:11]=2)[O:4][N:3]=1)=[O:18])([CH3:15])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178515664HCID 178515664, compound

Product 1

HCID 19596585HCID 19596585, compoundYield 82%

Procedure

3-Hydroxy-5-(2-thienyl)isoxazole (0.42 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.40 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 1(a) to obtain the title compound (0.63 g, 82%) as colorless crystals.

Sources & evidence

ORD record
ord-57b8f3db8c454cb3ba0e6d823a6bdea3
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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