tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596561, compound

HRID 612863Notes

Reaction equation

HRID 612863 reaction equation
[Cl:1][C:2]1[C:3]([OH:13])=[N:4][O:5][C:6]=1[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1.[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23]O)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23][O:13][C:3]1[C:2]([Cl:1])=[C:6]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)[O:5][N:4]=1)=[O:20])([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178519004HCID 178519004, compound

Product 1

HCID 19596561HCID 19596561, compoundYield 64%

Procedure

4-Chloro-3-hydroxy-5-(3-pyridyl)isoxazole (0.49 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.40 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 1(a) to obtain the title compound (0.54 g, 63%) as colorless crystals.

Sources & evidence

ORD record
ord-c390093d3a1c485780ac0e1533a17d12
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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