Triphenylphosphine → HCID 19596650, compound

Participants

Reaction Steps

Triphenylphosphine (0.45 g) was dissolved in tetrahydrofuran (5 ml), and diethyl azodicarboxylate (0.27 ml) was added dropwise to the solution under ice-cooling with stirring, and the resulting mixture was stirred at the same temperature for 30 minutes. Then, 2-(N-tert-butoxycarbonylamino)ethanol (0.20 g) and 3-hydroxy-5-(2-methoxyphenyl)isoxazole (0.22 g) were added to the reaction mixture, followed by stirring of the resulting mixture under ice-cooling for 10 minutes and at room temperature for 24 hours. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=4/1) to obtain the title compound (0.33 g, 86%) as colorless crystals.

Provenance & Evidence