tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596493, compound

HRID 612866Notes

Reaction equation

HRID 612866 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH3:14])[CH:8]=2)[O:4][N:3]=1.[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24]O)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][O:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH3:14])[CH:8]=2)[O:4][N:3]=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178489820HCID 178489820, compound

Product 1

HCID 19596493HCID 19596493, compoundYield 82%

Procedure

3-Hydroxy-5-(3-methoxyphenyl)isoxazole (0.22 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.20 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.31 g, 82%) as a colorless powder.

Sources & evidence

ORD record
ord-7a9114d0721947ef9ca4b8ffa4a4aabc
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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