tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596653, compound

HRID 612868Notes

Reaction equation

HRID 612868 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[C:10]([OH:13])[CH:9]=1.[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23]O)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23][O:13][C:10]1[CH:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[O:12][N:11]=1)=[O:20])([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178515541HCID 178515541, compound

Product 1

HCID 19596653HCID 19596653, compoundYield 88%

Procedure

5-(2-Chlorophenyl)-3-hydroxy-isoxazole (0.23 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.20 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.35 g, 88%) as a colorless powder.

Sources & evidence

ORD record
ord-74b84553933c4322a826af6908f7a61f
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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