tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596551, compound

HRID 612869Notes

Reaction equation

HRID 612869 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][N:11]=[C:10]([OH:13])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23]O)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23][O:13][C:10]1[CH:9]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[O:12][N:11]=1)=[O:20])([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178515585HCID 178515585, compound

Product 1

HCID 19596551HCID 19596551, compoundYield 85.3%

Procedure

5-(3-Chlorophenyl)-3-hydroxyisoxazole (0.23 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.20 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.34 g, 85%) as a colorless powder.

Sources & evidence

ORD record
ord-de62be2b81804699abd66b34c252250a
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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