tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596444, compound

HRID 612881Notes

Reaction equation

HRID 612881 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[O:4][N:3]=1.[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23]O)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23][O:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[O:4][N:3]=1)=[O:20])([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178423842HCID 178423842, compound

Product 1

HCID 19596444HCID 19596444, compoundYield 82%

Procedure

3-Hydroxy-5-(4-methylphenyl)isoxazole (1.5 g) and 2-(N-tert-butoxycarbonylamino)ethanol (1.5 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (2.2 g, 82%) as a colorless powder.

Sources & evidence

ORD record
ord-756e784b69024cadb1a46ffd2a80db16
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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