tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596562, compound

HRID 612882Notes

Reaction equation

HRID 612882 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[O:4][N:3]=1.[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26]O)=[O:23])([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26][O:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([C:13]([F:14])([F:16])[F:15])=[CH:11][CH:12]=2)[O:4][N:3]=1)=[O:23])([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178515592HCID 178515592, compound

Product 1

HCID 19596562HCID 19596562, compoundYield 81%

Procedure

3-Hydroxy-5-(4-trifluoromethylphenyl)isoxazole (0.2 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.15 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.26 g, 81%) as a colorless powder.

Sources & evidence

ORD record
ord-3fd8eb4bc58e4fab8aefae2ff2188ae1
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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