tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596528, compound

HRID 612883Notes

Reaction equation

HRID 612883 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([OH:13])[CH:9]=2)=[CH:4][CH:3]=1.[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23]O)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23][O:13][C:10]1[CH:9]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[O:12][N:11]=1)=[O:20])([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178515625HCID 178515625, compound

Product 1

HCID 19596528HCID 19596528, compoundYield 74.1%

Procedure

5-(4-Fluorophenyl)-3-hydroxyisoxazole (0.06 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.06 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.08 g, 74%) as a colorless powder.

Sources & evidence

ORD record
ord-98086ddd22f14f42a1dbf83f134c0d0a
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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