tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596694, compound

HRID 612884Notes

Reaction equation

HRID 612884 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][CH:8]=2)[O:4][N:3]=1.[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26]O)=[O:23])([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26][O:1][C:2]1[CH:6]=[C:5]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][CH:8]=2)[O:4][N:3]=1)=[O:23])([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178515512HCID 178515512, compound

Product 1

HCID 19596694HCID 19596694, compoundYield 89.4%

Procedure

3-Hydroxy-5-(1-naphthyl)isoxazole (0.20 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.17 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.30 g, 89%) as a colorless powder.

Sources & evidence

ORD record
ord-41ef82ab7b1a4c00a29913fff1f2178e
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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