tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596620, compound

HRID 612885Notes

Reaction equation

HRID 612885 reaction equation
[Br:1][C:2]1[C:3]([OH:13])=[N:4][O:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23]O)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[Br:1][C:2]1[C:3]([O:13][CH2:23][CH2:22][NH:21][C:19]([O:18][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:20])=[N:4][O:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178518996HCID 178518996, compound

Product 1

HCID 19596620HCID 19596620, compoundYield 81.4%

Procedure

4-Bromo-3-hydroxy-5-phenylisoxazole (0.2 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.15 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.26 g, 81%) as a colorless powder.

Sources & evidence

ORD record
ord-bda4f3e1c3034da0b0bfa369b6df6927
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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