tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596618, compound

HRID 612886Notes

Reaction equation

HRID 612886 reaction equation
[OH:1][C:2]1[C:6]([I:7])=[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:4][N:3]=1.[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23]O)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23][O:1][C:2]1[C:6]([I:7])=[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:4][N:3]=1)=[O:20])([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178519002HCID 178519002, compound

Product 1

HCID 19596618HCID 19596618, compoundYield 73.4%

Procedure

3-Hydroxy-4-iodo-5-phenylisoxazole (0.2 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.12 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.22 g, 73%) as a colorless powder.

Sources & evidence

ORD record
ord-3604dc625fb442c8b9a8edaf7351f6ba
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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