tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596563, compound

HRID 612887Notes

Reaction equation

HRID 612887 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([CH:13]([CH3:15])[CH3:14])=[CH:9][CH:8]=2)[O:4][N:3]=1.[C:16]([O:20][C:21]([NH:23][CH2:24][CH2:25]O)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([NH:23][CH2:24][CH2:25][O:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([CH:13]([CH3:15])[CH3:14])=[CH:9][CH:8]=2)[O:4][N:3]=1)=[O:22])([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178438897HCID 178438897, compound

Product 1

HCID 19596563HCID 19596563, compoundYield 77%

Procedure

3-Hydroxy-5-(4-isopropylphenyl)isoxazole (0.2 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.17 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.26 g, 77%) as a colorless powder.

Sources & evidence

ORD record
ord-eba28191f35b4b598d5e99a853f10015
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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