tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596647, compound

HRID 612890Notes

Reaction equation

HRID 612890 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:9][CH:8]=2)[O:4][N:3]=1.[C:20]([O:24][C:25]([NH:27][CH2:28][CH2:29]O)=[O:26])([CH3:23])([CH3:22])[CH3:21]>>[C:20]([O:24][C:25]([NH:27][CH2:28][CH2:29][O:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:11][CH:12]=2)[O:4][N:3]=1)=[O:26])([CH3:23])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178515643HCID 178515643, compound

Product 1

HCID 19596647HCID 19596647, compoundYield 74%

Procedure

3-Hydroxy-5-(4-phenoxyphenyl)isoxazole (0.2 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.14 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.23 g, 74%) as a colorless powder.

Sources & evidence

ORD record
ord-831c34e8cbc948d49ed164c1bdab96ea
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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