tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596531, compound

HRID 612893Notes

Reaction equation

HRID 612893 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[O:13][N:12]=[C:11]([OH:14])[CH:10]=1.[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24]O)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][O:14][C:11]1[CH:10]=[C:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[O:13][N:12]=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178515598HCID 178515598, compound

Product 1

HCID 19596531HCID 19596531, compoundYield 81%

Procedure

5-(2,4-Dichlorophenyl)-3-hydroxyisoxazole (0.2 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.17 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.26 g, 81%) as a colorless powder.

Sources & evidence

ORD record
ord-a7fe0502dc0f468ca8d63bea44e619ac
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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