tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596475, compound

HRID 612894Notes

Reaction equation

HRID 612894 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[O:13][N:12]=[C:11]([OH:14])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24]O)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][O:14][C:11]1[CH:10]=[C:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[O:13][N:12]=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178515610HCID 178515610, compound

Product 1

HCID 19596475HCID 19596475, compoundYield 85%

Procedure

5-(3,4-Dichlorophenyl)-3-hydroxyisoxazole (0.3 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.23 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.41 g, 85%) as a colorless powder.

Sources & evidence

ORD record
ord-ba0f96ff0e84468d8afce08efb1caaad
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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