tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596730, compound

HRID 612895Notes

Reaction equation

HRID 612895 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[O:13][N:12]=[C:11]([OH:14])[CH:10]=1.[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24]O)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][O:14][C:11]1[CH:10]=[C:9]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([Cl:8])[C:2]=2[Cl:1])[O:13][N:12]=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178515583HCID 178515583, compound

Product 1

HCID 19596730HCID 19596730, compoundYield 77%

Procedure

5-(2,3-Dichlorophenyl)-3-hydroxyisoxazole (0.3 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.23 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.37 g, 77%) as a colorless powder.

Sources & evidence

ORD record
ord-aeab844744554f67af49f380cc0e2220
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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