tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596468, compound

HRID 612896Notes

Reaction equation

HRID 612896 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[O:13][N:12]=[C:11]([OH:14])[CH:10]=1.[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24]O)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][O:14][C:11]1[CH:10]=[C:9]([C:3]2[C:4]([Cl:8])=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[O:13][N:12]=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178515669HCID 178515669, compound

Product 1

HCID 19596468HCID 19596468, compoundYield 65%

Procedure

5-(2,6-Dichlorophenyl)-3-hydroxyisoxazole (0.3 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.23 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.31 g, 65%) as a colorless powder.

Sources & evidence

ORD record
ord-88021cefa8434b1896b524d833f3eb56
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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