Methyl iodide → HCID 19596724, compound

HRID 612904Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:16]=[C:15]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][C:18]=2[Cl:24])[O:14][N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:25]I>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:16]=[C:15]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([CH3:25])[C:18]=2[Cl:24])[O:14][N:13]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 19596531HCID 19596531, compound

Product 1

HCID 19596724HCID 19596724, compoundYield 45%

Procedure

3-(2-(N-tert-Butoxycarbonylamino)ethoxy)-5-(2,4-dichlorophenyl)isoxazole (0.3 g) and methyl iodide (0.08 ml) were subjected to reaction and post-treatment in a similar manner to that described in Example 14(a) to obtain the title compound (0.14 g, 45%) as a colorless powder.

Sources & evidence

ORD record: ord-c674df64d28c455eb02a4c0f7919e09a
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06005116

Reaction notes

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