tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596490, compound

HRID 612908Notes

Reaction equation

HRID 612908 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:10][N:9]=[C:8]([OH:11])[C:7]=1[CH:12]([CH3:14])[CH3:13].[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24]O)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][O:11][C:8]1[C:7]([CH:12]([CH3:14])[CH3:13])=[C:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)[O:10][N:9]=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178439789HCID 178439789, compound

Product 1

HCID 19596490HCID 19596490, compoundYield 83.3%

Procedure

5-(2-Furyl)-3-hydroxy-4-isopropylisoxazole (0.2 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.18 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.29 g, 83%) as a colorless powder.

Sources & evidence

ORD record
ord-f5c88894b5fe41cabaf342b18232e851
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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