tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596739, compound

HRID 612909Notes

Reaction equation

HRID 612909 reaction equation
[C:1]([C:5]1[C:6]([OH:16])=[N:7][O:8][C:9]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26]O)=[O:23])([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26][O:16][C:6]1[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[C:9]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[O:8][N:7]=1)=[O:23])([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178441387HCID 178441387, compound

Product 1

HCID 19596739HCID 19596739, compoundYield 64.3%

Procedure

4-(tert-Butyl)-3-hydroxy-5-phenylisoxazole (0.15 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.12 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.16 g, 64%) as a colorless powder.

Sources & evidence

ORD record
ord-76b510882d9b4e3c827e42061b28241f
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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