tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596481, compound

HRID 612910Notes

Reaction equation

HRID 612910 reaction equation
[CH:1]1([C:4]2[C:5]([OH:15])=[N:6][O:7][C:8]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:3][CH2:2]1.[C:16]([O:20][C:21]([NH:23][CH2:24][CH2:25]O)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([NH:23][CH2:24][CH2:25][O:15][C:5]1[C:4]([CH:1]2[CH2:3][CH2:2]2)=[C:8]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[O:7][N:6]=1)=[O:22])([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178518997HCID 178518997, compound

Product 1

HCID 19596481HCID 19596481, compoundYield 74%

Procedure

4-Cyclopropyl-3-hydroxy-5-phenylisoxazole (0.2 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.18 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.25 g, 74%) as a colorless powder.

Sources & evidence

ORD record
ord-f4123062d63b442d85af49069b16659b
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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