tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596595, compound

HRID 612911Notes

Reaction equation

HRID 612911 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[O:13][N:12]=[C:11]([OH:14])[C:10]=1[CH:15]([CH3:17])[CH3:16].[C:18]([O:22][C:23]([NH:25][CH2:26][CH2:27]O)=[O:24])([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23]([NH:25][CH2:26][CH2:27][O:14][C:11]1[C:10]([CH:15]([CH3:17])[CH3:16])=[C:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[O:13][N:12]=1)=[O:24])([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178439786HCID 178439786, compound

Product 1

HCID 19596595HCID 19596595, compoundYield 86%

Procedure

5-(2,4-Dichlorophenyl)-3-hydroxy-4-isopropylisoxazole (0.06 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.04 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.078 g, 86%) as a colorless oil.

Sources & evidence

ORD record
ord-afc051d20c88435aad75603bdc832330
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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