tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596529, compound

HRID 612912Notes

Reaction equation

HRID 612912 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[C:10]([OH:13])[C:9]=1[CH:14]([CH3:16])[CH3:15].[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26]O)=[O:23])([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26][O:13][C:10]1[C:9]([CH:14]([CH3:16])[CH3:15])=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[O:12][N:11]=1)=[O:23])([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178439783HCID 178439783, compound

Product 1

HCID 19596529HCID 19596529, compoundYield 72%

Procedure

5-(2-Chlorophenyl)-3-hydroxy-4-isopropylisoxazole (0.13 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.1 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.15 g, 72%) as a colorless powder.

Sources & evidence

ORD record
ord-925352abac344005823ef5496bf96563
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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