tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596581, compound

HRID 612913Notes

Reaction equation

HRID 612913 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([OH:13])[C:9]=2[CH:14]([CH3:16])[CH3:15])=[CH:4][CH:3]=1.C(OC([NH:24][CH2:25][CH2:26]O)=O)(C)(C)C>>[ClH:1].[NH2:24][CH2:25][CH2:26][O:13][C:10]1[C:9]([CH:14]([CH3:16])[CH3:15])=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[O:12][N:11]=1

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178439784HCID 178439784, compound

Product 1

HCID 19596581HCID 19596581, compoundYield 189.8%

Procedure

5-(4-Chlorophenyl)-3-hydroxy-4-isopropylisoxazole (0.15 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.11 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.19 g, 79%) as a colorless powder.

Sources & evidence

ORD record
ord-b791c62d6dba43f3b16c3be9224c84d1
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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