tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596712, compound

HRID 612914Notes

Reaction equation

HRID 612914 reaction equation
[CH2:1]([C:4]1[C:5]([OH:15])=[N:6][O:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH:2]=[CH2:3].[C:16]([O:20][C:21]([NH:23][CH2:24][CH2:25]O)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[CH2:1]([C:4]1[C:5]([O:15][CH2:25][CH2:24][NH:23][C:21]([O:20][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:22])=[N:6][O:7][C:8]=1[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178439782HCID 178439782, compound

Product 1

HCID 19596712HCID 19596712, compoundYield 91.7%

Procedure

4-Allyl-3-hydroxy-5-phenylisoxazole (1.00 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.96 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 1(a) to obtain the title compound (1.57 g, 91%) as colorless crystals.

Sources & evidence

ORD record
ord-0051dfa95c5f4c1788b82ecfcd7d3b21
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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