tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596623, compound

HRID 612915Notes

Reaction equation

HRID 612915 reaction equation
[OH:1][C:2]1[C:6]([CH2:7][C:8]#[CH:9])=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:4][N:3]=1.[C:16]([O:20][C:21]([NH:23][CH2:24][CH2:25]O)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([NH:23][CH2:24][CH2:25][O:1][C:2]1[C:6]([CH2:7][C:8]#[CH:9])=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:4][N:3]=1)=[O:22])([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178439781HCID 178439781, compound

Product 1

HCID 19596623HCID 19596623, compoundYield 84%

Procedure

3-Hydroxy-5-phenyl-4-propargylisoxazole (1.00 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.96 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 1(a) to obtain the title compound (1.44 g, 84%) as a colorless oil.

Sources & evidence

ORD record
ord-138ad3f4b8564698a9d1a2db39eed929
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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