tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596701, compound

HRID 612916Notes

Reaction equation

HRID 612916 reaction equation
[OH:1][C:2]1[C:6]([CH2:7][CH:8]([CH3:10])[CH3:9])=[C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:4][N:3]=1.[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26]O)=[O:23])([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26][O:1][C:2]1[C:6]([CH2:7][CH:8]([CH3:10])[CH3:9])=[C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:4][N:3]=1)=[O:23])([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178441388HCID 178441388, compound

Product 1

HCID 19596701HCID 19596701, compoundYield 84.2%

Procedure

3-Hydroxy-4-isobutyl-5-phenylisoxazole (217 mg) and 2-(N-tert-butoxycarbonylamino)ethanol (193 mg) were subjected to reaction and post-treatment in a similar manner to that described in Example l(a) to obtain the title compound (303 mg, 84%) as colorless crystals.

Sources & evidence

ORD record
ord-e6161bc4b4b9484bb2d903bc354ed919
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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