tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596450, compound

HRID 612919Notes

Reaction equation

HRID 612919 reaction equation
[OH:1][C:2]1[C:6]([CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])=[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:4][N:3]=1.[C:18]([O:22][C:23]([NH:25][CH2:26][CH2:27]O)=[O:24])([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23]([NH:25][CH2:26][CH2:27][O:1][C:2]1[C:6]([CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])=[C:5]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[O:4][N:3]=1)=[O:24])([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178442267HCID 178442267, compound

Product 1

HCID 19596450HCID 19596450, compoundYield 82%

Procedure

3-Hydroxy-4-pentyl-5-phenylisoxazole (231 mg) and 2-(N-tert-butoxycarbonylamino)ethanol (193 mg) were subjected to reaction and post-treatment in a similar manner to that described in Example 1(a) to obtain the title compound (305 mg, 82%) as a colorless oil.

Sources & evidence

ORD record
ord-586cca50d7744fdfb9b135ad7634d1f8
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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