tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596497, compound

HRID 612921Notes

Reaction equation

HRID 612921 reaction equation
[OH:1][C:2]1[C:6]([CH:7]([CH3:9])[CH3:8])=[C:5]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[O:4][N:3]=1.[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24]O)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][O:1][C:2]1[C:6]([CH:7]([CH3:9])[CH3:8])=[C:5]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[O:4][N:3]=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178439790HCID 178439790, compound

Product 1

HCID 19596497HCID 19596497, compoundYield 86%

Procedure

3-Hydroxy-4-isopropyl-5-(2-thienyl)isoxazole (209 mg) and 2-(N-tert-butoxycarbonylamino)ethanol (193 mg) were subjected to reaction and post-treatment in a similar manner to that described in Example 1(a) to obtain the title compound (301 mg, 86%) as colorless crystals.

Sources & evidence

ORD record
ord-76d109ec2aa046fe93da03554155aecd
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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