4-Fluoro-3-methoxymethoxy-5-phenylisoxazole → HCID 178519001, compound

HRID 612924Notes

Reaction equation

HRID 612924 reaction equation
[F:1][C:2]1[C:3]([O:13]COC)=[N:4][O:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>Cl.O1CCOCC1>[F:1][C:2]1[C:3]([OH:13])=[N:4][O:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 1

HCID 195967054-Fluoro-3-methoxymethoxy-5-phenylisoxazole

Product 1

HCID 178519001HCID 178519001, compoundYield 84.9%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

4-Fluoro-3-methoxymethoxy-5-phenylisoxazole (0.44 g) was dissolved in a solution of 4N hydrochloric acid/dioxane (5.0 ml), and the solution was stirred at room temperature for one hour. After the reaction, the solvent was evaporated under reduced pressure and the crystal thus obtained was washed with dichloromethane (10 ml) to obtain the title compound (0.30 g, 83%) as colorless crystals.

Workup

  1. customAfter the reaction
  2. customthe solvent was evaporated under reduced pressure
  3. customthe crystal thus obtained
  4. washwas washed with dichloromethane (10 ml)

Sources & evidence

ORD record
ord-3a43b3fe7e1247b4bd4d2510ffd293a6
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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