HCID 19596499, compound → 3-(2-Dimethylaminoethoxy)-5-phenylisoxazole hydrochloride

HRID 612927Notes

Reaction equation

HRID 612927 reaction equation
[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][O:5][C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:8][N:7]=1.[ClH:18].O1CCOCC1>O1CCOCC1>[ClH:18].[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][O:5][C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:8][N:7]=1

Participants

4

Reactant 2

HCID 19596499HCID 19596499, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 195965323-(2-Dimethylaminoethoxy)-5-phenylisoxazole hydrochlorideYield 98%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-(2-Dimethylaminoethoxy)-5-phenylisoxazole (130 mg) was dissolved in dioxane (1.0 ml), and a solution of 4N hydrochloric acid/dioxane (0.2 ml) was added thereto, and the resulting mixture was allowed to stand at room temperature for 15 minutes. The solvent was evaporated under reduced pressure and the residue was washed with ethyl acetate (5 ml) to obtain the title compound (148 mg, 98%) as colorless crystals.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate (5 ml)

Sources & evidence

ORD record
ord-5017179cea2943169bd51fcbc8fb9bad
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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