tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596629, compound

HRID 612935Notes

Reaction equation

HRID 612935 reaction equation
[OH:1][C:2]1[C:6]([CH:7]([CH3:9])[CH3:8])=[C:5]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[O:4][N:3]=1.[C:16]([O:20][C:21]([NH:23][CH2:24][CH2:25]O)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([NH:23][CH2:24][CH2:25][O:1][C:2]1[C:6]([CH:7]([CH3:9])[CH3:8])=[C:5]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[O:4][N:3]=1)=[O:22])([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178439788HCID 178439788, compound

Product 1

HCID 19596629HCID 19596629, compoundYield 74%

Procedure

3-Hydroxy-4-isopropyl-5-(3-pyridyl)isoxazole (0.12 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.09 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 9(a) to obtain the title compound (0.14 g, 74%) as a colorless powder.

Sources & evidence

ORD record
ord-e2c109605c074c7ab223f0ac71337321
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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