tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596549, compound

HRID 612938Notes

Reaction equation

HRID 612938 reaction equation
[OH:1][C:2]1[C:6]([CH:7]([CH3:9])[CH3:8])=[C:5]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[O:4][N:3]=1.[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26]O)=[O:23])([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26][O:1][C:2]1[C:6]([CH:7]([CH3:9])[CH3:8])=[C:5]([C:10]2[CH:11]=[CH:12][C:13]([CH3:16])=[CH:14][CH:15]=2)[O:4][N:3]=1)=[O:23])([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178424104HCID 178424104, compound

Product 1

HCID 19596549HCID 19596549, compoundYield 82%

Procedure

3-Hydroxy-4-isopropyl-5-(4-methylphenyl)isoxazole (0.2 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.16 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 1 (a) to obtain the title compound (0.27 g, 82%) as a colorless powder.

Sources & evidence

ORD record
ord-a4d9a9d5f71b49d7a981129a3d2ca9cb
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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