HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-Benzyl 2-amino-3-methoxypropanoate hydrochloride → (S)-2-((S)-2-tert-butoxycarbonylamino-3-difluoromethoxy-propionylamino)-3-methoxy-propionic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-Benzyl 2-amino-3-methoxypropanoate hydrochloride | HCID 69153484 | — |
| Reactant | (S)-2-tert-Butoxycarbonylamino-3-difluoromethoxy-propionic acid | HCID 86709693 | — |
| Product | (S)-2-((S)-2-tert-butoxycarbonylamino-3-difluoromethoxy-propionylamino)-3-methoxy-propionic acid benzyl ester | HCID 90040871 | — |
Reaction Steps
The compound of Formula II(b)(ii) was prepared as an off-white foam in a similar manner as the compound of Formula II(a)(ii), described above, from the compound of Formula IV(a), (S)-2-tert-butoxycarbonylamino-3-difluoromethoxy-propionic acid and the compound of Formula V(b), (S)-2-amino-3-methoxy-propionic acid benzyl ester, hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09441012B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-8c426d448f92404ea77365e923e04078 |
| Source note | uspto-grants-2016_09 |