5-Methyl-2-pyrrolidone → 1-[2-(5-Methyl-2-oxopyrrolidin-1-yl)-4-pyridyl]-2,3-bis(methoxycarbonyl)-6,7-dimethoxynaphthalene

HRID 613011Notes

Reaction equation

HRID 613011 reaction equation
Br[C:2]1[CH:7]=[C:6]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=3)[CH:11]=[C:10]([C:22]([O:24][CH3:25])=[O:23])[C:9]=2[C:26]([O:28][CH3:29])=[O:27])[CH:5]=[CH:4][N:3]=1.[CH3:30][CH:31]1[NH:35][C:34](=[O:36])[CH2:33][CH2:32]1>>[CH3:30][CH:31]1[N:35]([C:2]2[CH:7]=[C:6]([C:8]3[C:17]4[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=4)[CH:11]=[C:10]([C:22]([O:24][CH3:25])=[O:23])[C:9]=3[C:26]([O:28][CH3:29])=[O:27])[CH:5]=[CH:4][N:3]=2)[C:34](=[O:36])[CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 220073291-(2-Bromo-4-pyridyl)-2,3-bis(methoxycarbonyl)-6,7-dimethoxynaphthalene

Product 1

HCID 220073521-[2-(5-Methyl-2-oxopyrrolidin-1-yl)-4-pyridyl]-2,3-bis(methoxycarbonyl)-6,7-dimethoxynaphthalene

Procedure

1-(2-Bromo-4-pyridyl)-2,3-bis(methoxycarbonyl)-6,7-dimethoxynaphthalene and 5-methyl-2-oxopyrrolidine are treated in the same manner as in Example 6-(2) to give 1-[2-(5-methyl-2-oxopyrrolidin-1-yl)-4-pyridyl]-2,3-bis(methoxycarbonyl)-6,7-dimethoxynaphthalene.

Sources & evidence

ORD record
ord-d2f54f036017494780a98a0944c0f68f
Source dataset
uspto-grants-1999_12
Patent number
US06005106

Reaction notes

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