Hydrochloric Acid → benzyl (2S)-2-[[(2S)-2-amino-3-(difluoromethoxy)propanoyl]amino]-3-phenyl-propanoate hydrochloride

Participants

Reaction Steps

Benzyl(2S)-2-[[(2S)-2-(tert-butoxycarbonylamino)-3 (difluoromethoxy)propanoyl]amino]-3-phenyl-propanoate (1.9 g, 3.86 mmol) was stirred in HCl, 2M in diethyl ether (12 mL), at room temperature overnight. The resulting suspension was diluted with hexanes and the filtered to collect the compound of Formula XVI(a) (1.65 g, quantitative yield) as a white solid. The product was used directly in the subsequent reaction.

Provenance & Evidence