HCID 54681506, compound → HCID 54681375, compound

HRID 613069Notes

Reaction equation

HRID 613069 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:5][C:4](=[O:14])[C:3]=1[CH:15](SC1C=CC=CC=1)[CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>[Ni].C(O)C>[OH:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:5][C:4](=[O:14])[C:3]=1[CH2:15][CH2:16][CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 1

HCID 54681506HCID 54681506, compound

Product 1

HCID 54681375HCID 54681375, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

The title compound was prepared by Method F using Raney-Nickel (Grace 3100), ethanol (15 mL), 4-hydroxy-6-phenyl-3-[3-phenyl-1-(phenylthio)propyl]-2H-pyran-2-one (0.150 g, 0.362 mmol). m.p. 195-196° C.; 1H NMR (400 MHz, DMSO-d6) δ1.73 (m, 2 H), 2.40 (t, 2 H), 2.60 (t, 2 H), 6.68 (s, 1 H), 7.23 (m, 5 H), 7.52 (m, 3 H), 7.74 (m, 2 H).

Sources & evidence

ORD record
ord-e7d2429f6c8149b091a7a45a89fbab75
Source dataset
uspto-grants-1999_12
Patent number
US06005103

Reaction notes

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