Ethyl benzoylacetate → 14895-21-7

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl benzoylacetate (150 g, 0.88 mmol) in 1,2-dichlorobenzene (150 mL) was added a trace amount of sodium bicarbonate. The reaction mixture was heated to reflux. A distillate of ethanol (approximately 20 mL) was collected. The reaction mixture was cooled to 0° C. Ether (100 mL) was added to induce crystallization. The reaction mixture was kept in the refrigerator overnight. The solid formed was collected and washed with ether: m.p. 171-173° C.; 1H NMR (250 MHz, DMSO-d6) δ6.91 (s, 1 H), 7.59 (m, 6 H), 7.87 (m, 4 H).

Provenance & Evidence