HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-[Bis(2-naphthalenylmethyl)amino]-4-hydroxy-6-phenyl-2H-pyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 2-Naphthalenecarboxaldehyde | HCID 6201 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 3-amino-4-hydroxy-6-phenyl-2H-pyran-2-one hydrochloride | HCID 54681289 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[Bis(2-naphthalenylmethyl)amino]-4-hydroxy-6-phenyl-2H-pyran-2-one | HCID 54681482 | — |
Reaction Steps
The title compound was prepared by Method D using 3-amino-4-hydroxy-6-phenyl-2H-pyran-2-one hydrochloride (0.250 g, 1.04 mmol), 1% acetic acid in dimethylformamide (10 mL), 2-naphthaldehyde (0.407 g, 2.60 mmol), sodium cyanoborohydride (0.164 g, 2.60 mmol). m.p. dec. 209; 1H NMR (250 MHz, DMSO-d6) δ4.46 (s, 4 H), 6.38 (s, 1 H), 7.44 (m, 8H), 7.77 (m, 13H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06005103 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-12135f71cc694e449b02c827e141c7e0 |
| Source note | uspto-grants-1999_12 |