Chlorotrimethylsilane → HCID 54737113, compound

Participants

Reaction Steps

The title compound was prepared by Method A using 4-[[(4-acetyl) phenoxy]methyl]benzoic acid methyl ester (2.0 g, 7.04 mmol), lithium hexamethyldisilazide (2.36 g, 14.08 mmol), chlorotrimethylsilane (2.38 g, 14.08 mmol) and diethyl ester of [(2-phenylethyl) thio]propanedioic acid (1.0 g, 3.05 mmol). m.p. 157-158° C.; 1H NMR (400 MHz, DMSO-d6) δ2.78 (t, 2 H), 2.97 (t, 2 H), 3.86 (s, 2 H), 5.31 (s, 2 H), 6.67 (s, 1 H), 7.17 (q, 4 H), 7.25 (m, 3 H), 7.61 (d, 2 H), 7.78 (d, 2H), 8.0 (d, 2H); IR (KBr) 3023, 2936, 2581, 1632, 1510, 1404, 1258, 1184, 1098, 1009, 818, 718 cm-1 ; MS (CI) m/e 517 (M+29, 7), 489 (M+H, 55), 384 (19), 149 (40), 105 (100).

Provenance & Evidence