Nitrogen → HCID 54681487, compound

Participants

Reaction Steps

A solution of methyl-[4-(1-oxoethyl)phenoxy]-acetate (2.50 g, 10.86 mmol) in CH2C12 (25.0 mL) was cooled to 0° C. (N2 atmosphere) and treated with triethylamine (3.03 mL, 21.7 mmol) followed by trimethylsilyltriflate (2.52 mL, 13.0 mmol). The solution was then warmed to ambient temperature, allowed to stir for 15 min., and subsequently quenched into a mixture of diethyl ether (50 mL) and saturated aqueous NaHCO3 (20 mL). The layers were separated and the organic layer washed with a 1:1 mixture of brine:saturated NaHCO3 (20 mL). The ethereal solution was then dried with Na2SO4 and the solvent removed in vacuo. The resulting silyl enol ether was then transferred to a flask containing diethyl 2-(thiophenyl)propane-1,3-dioate (0.97 g, 3.6 mmol). The mixture was then heated to 140° C. for 16 h. and allowed to cool to room temperature where it was submitted to chromatography (SiO2 -230 to 400 mesh, 100% CH2C12 to 2.0% MeOH / CH2C12) to provide an impure solid which was diluted with diethyl ether (20 mL) and extracted with saturated Na2CO3 (3×20 mL). The combined aqueous extracts were washed with diethyl ether (3×100 mL) and then acidifed with conc. HCl to pH 0. The mixture was then extracted with ethyl acetate (3×100 mL), the organic layers combined, dried with Na2SO4 and the solvent removed in vacuo. to provide the title compound (0.695 g, m.p. 186-188 ° C.). 1H NMR (300 MHz, DMSO-d6) δ13.175 (bs, 1 H), 12.425 (bs, 1 H), 7.809 (d, 2 H, J=9 Hz), 7.298-7.247 (m, 2 H), 7.149-7.004 (m, 5 H), 6.785 (s, 1 H), 4.804 (s, 2 H).

Provenance & Evidence