Triethylamine → HCID 54681307, compound

Participants

Reaction Steps

The title compound (0.691 g, m.p. 194 - 197° C.) was prepared in a similar manner to that demonstrated in the preparation of [4-[4-hydroxy-2-oxo-3- (phenylthio) -2H-pyran-6-yl]phenoxy]-acetic acid using the following: Methyl-[4-(1-oxoethyl)phenoxy]-acetate (2.00 g, 8.81 mmol), triethylamine (3.68 mL, 26.4 mmol), trimethylsilyltriflate (2.38 mL, 12.3 mmol), dichoromethane (20.0 mL), diethyl 2-(thiophenyl)propane-1,3-dioate (1.34 g, 5.00 mmol.), 1H NMR (400 MHz, DMSO-d6) δ7.585 (d, 2 H, J=9 Hz), 7.325-7.286 (m, 2 H), 7.178 (d, 3 H, J=7.5 Hz), 7.063 (d, 2 H, J=9 Hz), 4.784 (s, 2 H), 2.042 (s, 3 H).

Provenance & Evidence