Diethyl Ether → HCID 22220646, compound

HRID 613204Notes

Reaction equation

HRID 613204 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH3:7].[C:8]1([CH3:21])[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[C:9]=1[S:16]([NH:19]O)(=[O:18])=[O:17].CC[O:24]CC>ClCCl>[C:8]1([CH3:21])[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[C:9]=1[S:16]([O-:24])(=[O:18])=[O:17].[NH2:19][N+:3]1[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][CH:4]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 625104,5-DimethylthiazoleHCID 11009332O-mesitylenesulfonylhydroxylamine

Product 1

HCID 22220646HCID 22220646, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

An ice cold solution of the 4,5-dimethyl thiazole (2,26 g, 20 mmol) in dry dichloromethane (15 ml) was treated dropwise with a solution of o-mesitylenesulfonylhydroxylamine (4.3 g, 20 mmol) in dry dichloromethane (15 ml). After stirring for 2 hours at room temperature, anhydrous ether (10 ml) was added. On cooling, colorless needles of the title product, 3-amino-4,5-dimethyl-thiazolium mesitylenesulfonate, separated (3.48 g), m.p. 165-168° C.

Workup

  1. temperatureOn cooling
  2. customcolorless needles of the title product, 3-amino-4,5-dimethyl-thiazolium mesitylenesulfonate, separated (3.48 g), m.p. 165-168° C.

Sources & evidence

ORD record
ord-3e957919728b41d8b2c8dde00f093011
Source dataset
uspto-grants-1999_12
Patent number
US06007865

Reaction notes

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