HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-(4'-Fluorophenyl)-4-chloro-5-methylpyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2-(4'Fluorophenyl)-5-methyl-4-pyrimidinone | HCID 18784500 | — |
| Product | 2-(4'-Fluorophenyl)-4-chloro-5-methylpyrimidine | HCID 18784496 | — |
Reaction Steps
A mixture of 2-(4'-fluorophenyl)-5-methyl-4-pyrimidinone (0.79 g, 3.9 mmol) (from example 5) and phosphorous oxychloride (3 ml) is heated to reflux for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06008161 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-c4e16ceeae674b789e8c6304ef585435 |
| Source note | uspto-grants-1999_12 |