Hydrochloric Acid → H-Val-Pro-Val-CF2CF2CF3.hydrochloride

Participants

Reaction Steps

Bubble HCl gas into a stirred solution of Boc-Val-Pro-Val-CF2CF2CF3 (0.21 g, 0.37 mmol) in ethyl acetate (50 mL) and cool in an ice water bath. Treat with hydrogen chloride gas for 4 minutes. Stir the reaction mixture for 1 hour and warm to ambient temperature. Concentrate the reaction mixture and azeotrope with CCl4. Place under a high vacuum to give the title compound as a white solid. (Yield: 185 mg, 100%).

Provenance & Evidence