反应详情

温度

85 °C

A mixture of 1,3-dimethyl-4-chloro-1H-pyrazolo[3,4-b] quinoline (1.2 g, 0.005 mol), benzylamine (1.2 ml) and DMSO (3 ml) was heated at 80-90° C. for 3-4 hours. The reaction mixture was cooled to room temperature and then was poured into water. The mixture was extracted with CH2Cl2 (3×50 ml) and then the CH2Cl2 layers were combined and evaporated. The residue was purified by column chromatography on silca gel eluting with ethyl acetate to afford the product which was crystallized from ether/hexane to afford 1.2 g of 1,3-dimethyl-N-(phenylmethyl)-1H-pyrazolo[3,4-b]quinolin-4-amine, as a yellow solid, m.p. 105° C.

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionThe mixture was extracted with CH2Cl2 (3×50 ml)
3. customevaporated
4. customThe residue was purified by column chromatography on silca gel
5. washeluting with ethyl acetate
6. customto afford the product which
7. customwas crystallized from ether/hexane