Sodium Hydroxide → HCID 19591901, compound

HRID 613389Notes

Reaction equation

[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[CH2:10][CH2:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]2[CH2:22][CH:21]([CH2:23][C:24]([O:26]CC)=[O:25])[C:20]3[CH:29]=[CH:30][CH:31]=[CH:32][C:19]=3[CH2:18][C:17]=2[CH:33]=1.[OH-].[Na+]>CCO>[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[CH2:10][CH2:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]2[CH2:22][CH:21]([CH2:23][C:24]([OH:26])=[O:25])[C:20]3[CH:29]=[CH:30][CH:31]=[CH:32][C:19]=3[CH2:18][C:17]=2[CH:33]=1

Participants

Conditions

Temperature: 50 °C

Procedure

A mixture of ethyl (±)-10,11-dihydro-3-[3-(2-benzimidazolyl)-1-propyl]-5H-dibenzo[a,d]cycloheptene-10-acetate (236.3 mg, 0.54 mmole), 1.0 N NaOH (0.65 mL, 0.65 mmole), and absolute EtOH (4.8 mL) was warmed in an oil bath preset at 50° C. After 16 hr, the reaction was concentrated to dryness and the residue was purified by ODS chromatography (gradient: 35% MeOH/H2O, then 40% MeOH/H2O). Concentration followed by lyophilization gave the title compound (143 mg, 58%) as a colorless powder: HPLC (PRP-1®, 40% CH3CN/H2O containing 0.1% TFA) K'=1.5; 1H NMR (400 MHz, CD3OD) δ 7.41-7.49 (m, 2 H), 6.86-7.27 (m, 9 H), 4.24 (d, J=14.7 Hz, 1 H), 3.87 (d, J=14.7 Hz, 1 H), 3.73-3.85 (m, 1 H), 3.23-3.25 (m, 1 H, partially obscured by residual solvent signal), 2.80-2.93 (m, 3 H), 2.62 (t, J=7.5 Hz, 2 H), 2.56 (dd, J=14.4, 5.1 Hz, 1 H), 2.40 (dd, J=14.4, 9.7 Hz, 1 H), 2.05-2.17 (m, 2 H); MS (ES) m/e 411 (M+H)+. Anal. Calcd for C27H25N2O2Na. 1.5 H2O: C, 70.57; H, 6.14; N, 6.10. Found: C, 70.65; H, 5.95; N, 5.95.

Workup

concentrationthe reaction was concentrated to dryness
customthe residue was purified by ODS chromatography (gradient
concentrationConcentration

Sources & evidence

ORD record: ord-b183c510966c4417aa5696ad1e949ccd
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06008213

Reaction notes

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