HCID 10665616, compound → 2-{[2-(2,4-difluorophenyl)-1,1-difluoro-2-methoxy-3-(1H-1,2,4-triazol-1-yl)propyl]thio}-1-ethanol

HRID 613396Notes

Reaction equation

HRID 613396 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:24])([CH2:18][N:19]1[CH:23]=[N:22][CH:21]=[N:20]1)[C:10]([F:17])([F:16])[S:11][CH2:12][CH2:13][O:14]C.F[C:26]1C=C(F)C=CC=1C(O)(CN1C=NC=N1)C(F)(F)SCCO>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([O:24][CH3:26])([CH2:18][N:19]1[CH:23]=[N:22][CH:21]=[N:20]1)[C:10]([S:11][CH2:12][CH2:13][OH:14])([F:17])[F:16]

Participants

3

Reactant 2

HCID 10665616HCID 10665616, compoundHCID 15433416HCID 15433416, compound

Product 1

HCID 195931162-{[2-(2,4-difluorophenyl)-1,1-difluoro-2-methoxy-3-(1H-1,2,4-triazol-1-yl)propyl]thio}-1-ethanol

Procedure

In a similar manner to Example 1 except that 2-(2,4-difluorophenyl)-1,1-difluoro-1-[(2-methoxyethyl)thio]-3-(1H-1,2,4-triazol-1-yl)-2-propanol was replaced with 2-(2,4-difluorophenyl)-1,1-difluoro-1-[(2-hydroxyethyl)thio]-3-(1H-1,2,4-triazol-1-yl)-2-propanol, the experiment was carried out, whereby 2-{[2-(2,4-difluorophenyl)-1,1-difluoro-2-methoxy-3-(1H-1,2,4-triazol-1-yl)propyl]thio}-1-ethanol was obtained as colorless crystals.

Sources & evidence

ORD record
ord-ae34e2dee2b048f086af9b1c90b7fbeb
Source dataset
uspto-grants-1999_12
Patent number
US06008239

Reaction notes

Loading…